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07 September 2017, 01:28 | Ken Black
Nadal chases a shot during his win over Mayer
Federer is, bidding for a sixth US Open and 20th major, and is playing Philipp Kohlschreiber in their round of 16 clash.
Nadal easily returned to the tournament quarterfinals for the first time in four years by routing Alexandr Dolgopolov 6-2, 6-4, 6-1 on Monday.
The top-seeded Nadal wrapped up the rout in just over 90 minutes, then waited to see if he would finally face Federer in the only Grand Slam tournament where they have never met.
It also represented a newfound dominance in this year's event after his straight-sets win over Feliciano Lopez in the third round.
"I think I had quite high expectations, and obviously I knew I had quite an OK draw, so there was nobody, like, unbeatable for me", Pliskova said.
Del Potro, the 2009 champion at Flushing Meadows, dropped the opening two sets of the fourth-round match.
Federer is looking forward to facing an old foe.
That was clear as del Potro shook off the effects of a fever and erased two set points while coming back from a big deficit to eliminated No. 6 Dominic Thiem 1-6, 2-6, 6-1, 7-6 (1), 6-4.
There was no need for a fifth set Monday thanks largely to the No. 3 seed's serve.
Blue skies and bright sunshine greeted fans at the U.S. Open on Monday, where world number one Rafa Nadal and third seed Roger Federer were scheduled to play under an open roof at Arthur Ashe Stadium.
Kanepi is back to her best after nearly two years off the courts because of an injury and a virus, and Keys will be aiming to join compatriots Sloane Stephens and Venus Williams in the last-four.
The No. 1 seed is back into the quarters in Flushing Meadows for the first time since 2013, when he won his second of two U.S. Open titles.
Federer brings an 11-0 record against No. 33 seed Philipp Kohlschreiber into their night matchup.
Thiem, who was forced to quit with an injury against del Potro at the same stage in 2016, celebrated his 24th birthday on Sunday. He will face Federer in the quarterfinals.
Swiss Federer, chasing a record-extending 20th grand slam title, takes on Argentine Juan Martin Del Potro, the man who beat him in the 2009 final in NY. "I will try to do my best - I have nothing to lose", Rublev said.
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