The 29-year-old had been suffering from an Achilles problem earlier this week but was named in the starting XI on Saturday afternoon, despite Belgium having already sealed progress to the World Cup.
With Pogba not expected back until November Ander Herrera, who has played a bit-part role so far this season, could be recalled for the crunch game at Anfield.
A potential added injury to the growing list could not come at a worse time for United, who return after the global break for a crunch fixture with bitter rivals Liverpool. Four goals from 8 games in all competitions have equaled the number of goals scored by Fellaini last season from 47 parties.
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How hurricanes could distort September jobs numbers
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